Detailing the Opportunities for Epigenetic Drug Discovery & Development in CNS Tumors to Inform Pipeline Decision Making

Time: 1:45 pm
day: Day One

Details:

  • Glioblastoma is one of the first tumors where a single epigenetic modification, the methylation of the MGMT gene, was found to be of clinical relevance
  • Cataloguing the additional alterations (IDH1/2 mutations and histone 3 variants) that either interfere with epigenetic modifier enzymes or alter alter global H3K27me3 levels
  • Overviewing the landscape of opportunities for therapeutic targeting of epigenetic drivers in CNS tumors

Speakers: