Shikhar Sharma

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Company: Pfizer

Job title: Research Fellow

Seminars:

Translating Established Targets: Potent anti-Tumor Activity of a KAT6A/KAT6B Inhibitor PF-9363/CTx-648 in KAT6A dysregulated ER+ Breast Cancer 2:45 pm

Understanding molecular dysregulation of KAT6A has been observed in several cancers, including amplifications in breast, lung, ovarian cancer along with oncogenic fusions in AML Examining CTx-648 (PF-9363), a first-in-class potent KAT6A/KAT6B inhibitor that possess high selectivity versus other MYST family members (KAT7, KAT5, KAT8) Learn how CTx-648 (PF-9363) inhibits expression of ESR1 expression leading to…Read more

day: Day Two

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